Journal: iScience

Article Title: RNA N4-acetylcytidine modification in human cancers: from molecular function to oncogenic mechanisms

doi: 10.1016/j.isci.2026.115080

Figure Lengend Snippet: Organ-specific landscape of ac4C-modified transcripts and their therapeutic implications in human cancers The schematic human model summarizes the key ac4C-regulated oncogenic targets across different cancer types, their roles in tumor pathogenesis within specific organs, and the corresponding therapeutic strategies. In the Target column: upward (↑) and downward (↓) arrows denote the upregulation or downregulation, respectively, of specific mRNA/protein expression. Rightward arrows (→) indicate the activation of downstream signaling pathways or molecular consequences. The Therapy column lists therapeutic strategies, including pharmacological inhibitors and rational combinations that target the NAT10-ac4C axis and have shown efficacy in preclinical models for the respective cancer types.

Article Snippet: Liquid biopsy platforms detecting ac4C-modified transcripts in circulating tumor cells or exosomes from blood and other biofluids (e.g., ascites and cerebrospinal fluid) represent particularly promising avenues for clinical translation.

Techniques: Modification, Expressing, Activation Assay, Protein-Protein interactions